Long-Term Use of Proton Pump Inhibitors Linked to Increased Risk of Stomach Cancer

Probably good to know for people who suffer from the associated problems the drugs are used for.

A class of drugs commonly used to treat acid reflux and heartburn has been linked to a greater-than-doubled risk of developing stomach cancer, a recent study has shown.

Proton pump inhibitors (PPIs) are used to suppress acid production in the stomach and are among the most widely sold drugs in the world, but a new study reveals that long-term use of the medicine can increase stomach cancer risks by almost 250 percent.

The risks are associated with a bacterium called Helicobacter pylori, carried by more than half of the world’s population – most often harmlessly, but in a small percentage of people, the bug has been tied to the development of stomach cancer.


“Proton pump inhibitors (PPIs) are an important treatment of Helicobacter pyloriinfection and have good safety records for short-term use,” says researcher Ian Wong from University College London.

“However, unnecessary long-term use should be avoided.”