A New Tool In Improving Mental Health — Building Design

Buildings can be designed in ways that allow for more of the interior to be exposed to sunlight and nature. In the time of the pandemic, more sunlight in rooms can act as a natural disinfectant, and one study found that people had better mental health after taking walks through nature.

For decades, psychiatric hospitals were grim settings where patients were crowded into common rooms by day and dorms at night. But new research into the health effects of our surroundings is spurring the development of facilities that feel more residential, with welcoming entrances, smaller living units within larger buildings and a variety of gathering spaces. Nature plays a big role: Windows provide views of greenery, landscapes decorate walls, and outdoor areas give patients and staff access to fresh air and sunlight.

The new approach, promoted as healing and therapeutic, has produced environments that are more calming and supportive. And it feels particularly timely, given the surge in mental health issues created by the pandemic.

“We’ve been talking about this for a really long time,” said Mardelle McCuskey Shepley, chair of the department of design and environmental analysis in Cornell University’s College of Human Ecology in New York. “It’s only now that it’s gaining momentum.”

Even before the pandemic, the number of Americans affected by mental illness was at a new high. One in five adults was experiencing depression, bipolar disorder, schizophrenia, post-traumatic stress or some other malady, according to the National Institute of Mental Health. The rates were significantly higher for adolescents (about 50%) and young adults (about 30%).

Nearly a year into the pandemic, more people are suffering. Young adults and Black and Latino people of all ages are reporting increased levels of anxiety, depression and substance abuse, according to a survey from the Centers for Disease Control and Prevention. A recent Gallup poll showed that Americans felt their mental health was “worse than it has been at any point in the last two decades.”

Demand for treatment has soared, and the construction of mental health facilities has been outpacing that of other specialty hospitals. Last year, 40% of the specialty hospitals under construction were psychiatric hospitals and behavioural health centres, according to the American Society for Health Care Engineering.

Architecture and interior design firms with expertise in health care buildings have reported an increase in activity. At design firm Architecture+ in Troy, New York, one or two major mental health facilities are typically in the pipeline, with total construction costs for those projects at about $250 million a year, said Francis Murdock Pitts, a principal and founding partner. Last year, the firm was working on 16 large mental health projects totalling about $1.9 billion.

His firm and others like it have medical planners on staff who help translate research into “evidence-based” designs. “This isn’t just about being warm and fuzzy,” Pitts said.

For instance, exposure to nature has been shown to lower cortisol levels, a measure of stress. Adding healing gardens and other greenery can help soothe agitated patients and give staff a place to decompress.

Research specific to mental health care settings is also coming into play. Studies have shown that reducing crowding by providing private rooms and multiple communal spaces may lessen patient and employee stress and aggression. Lowering noise — eliminating unnecessary beeping of medical equipment, for example — can also help. If patients are less stressed, they may make faster and more lasting progress during treatment, experts say.

But because mental health issues vary widely, there is no one-size-fits-all design solution. And safety — for both patients and staff — remains paramount.

Codes and guidelines fine-tuned over many years have sought to eliminate room features that patients have used to harm themselves and others. Window glazing is made of polycarbonate compounds to reduce breaking. Doors are hung on quick-release hinges to allow staff to enter a room if a patient is barricaded in. Plumbing and other fixtures have been designed to prevent the possibility of hanging or strangulation.

Such safety measures are crucial, but “you don’t want it to get to the point where it looks prisonlike,” said Shary Adams, a principal at HGA, a national design firm. At the same time that the built environment must be engineered to ensure safety, there is also a move to give patients some control over their surroundings. Manual thermostats allow patients to adjust the temperature in their rooms, for example, and dimmer switches let them modulate the lights.

The location of mental health facilities is changing, too. Psychiatric institutions used to be tucked away, but today they are likely to be part of hospital campuses or otherwise conveniently situated. They often combine inpatient rooms for those who need round-the-clock monitoring and areas for outpatient services, allowing patients to shift to less intensive care in the same building.

Lifelong Exercise Shown to Slow Aging

The benefits of exercise are underrated much too often.

Researchers at the University of Birmingham and King’s College London have found that staying active keeps the body young and healthy.

The researchers set out to assess the health of older adults who had exercised most of their adult lives to see if this could slow down ageing.

The study recruited 125 amateur cyclists aged 55 to 79, 84 of which were male and 41 were female. The men had to be able to cycle 100 km in under 6.5 hours, while the women had to be able to cycle 60 km in 5.5 hours. Smokers, heavy drinkers and those with high blood pressure or other health conditions were excluded from the study.

The participants underwent a series of tests in the laboratory and were compared to a group of adults who do not partake in regular physical activity. This group consisted of 75 healthy people aged 57 to 80 and 55 healthy young adults aged 20 to 36.

The study showed that loss of muscle mass and strength did not occur in those who exercise regularly. The cyclists also did not increase their body fat or cholesterol levels with age and the men’s testosterone levels also remained high, suggesting that they may have avoided most of the male menopause.

More surprisingly, the study also revealed that the benefits of exercise extend beyond muscle as the cyclists also had an immune system that did not seem to have aged either.

An organ called the thymus, which makes immune cells called T cells, starts to shrink from the age of 20 and makes less T cells. In this study, however, the cyclists’ thymuses were making as many T cells as those of a young person.

The findings come as figures show that less than half of over 65s do enough exercise to stay healthy and more than half of those aged over 65 suffer from at least two diseases.* Professor Janet Lord, Director of the Institute of Inflammation and Ageing at the University of Birmingham, said: “Hippocrates in 400 BC said that exercise is man’s best medicine, but his message has been lost over time and we are an increasingly sedentary society.

“However, importantly, our findings debunk the assumption that ageing automatically makes us more frail.

“Our research means we now have strong evidence that encouraging people to commit to regular exercise throughout their lives is a viable solution to the problem that we are living longer but not healthier.”

Dr Niharika Arora Duggal, also of the University of Birmingham, said: “We hope these findings prevent the danger that, as a society, we accept that old age and disease are normal bedfellows and that the third age of man is something to be endured and not enjoyed.”

Professor Stephen Harridge, Director of the Centre of Human & Aerospace Physiological Sciences at King’s College London, said: “The findings emphasise the fact that the cyclists do not exercise because they are healthy, but that they are healthy because they have been exercising for such a large proportion of their lives.

“Their bodies have been allowed to age optimally, free from the problems usually caused by inactivity. Remove the activity and their health would likely deteriorate.”

Norman Lazarus, Emeritus Professor at King’s College London and also a master cyclist and Dr Ross Pollock, who undertook the muscle study, both agreed that: “Most of us who exercise have nowhere near the physiological capacities of elite athletes.

“We exercise mainly to enjoy ourselves. Nearly everybody can partake in an exercise that is in keeping with their own physiological capabilities.

“Find an exercise that you enjoy in whatever environment that suits you and make a habit of physical activity. You will reap the rewards in later life by enjoying an independent and productive old age.”

Important COVID-19 Antibody Drugs Aren’t Being Used Enough

“Antibody drugs from Regeneron and Eli Lilly could reduce hospitalizations from Covid-19 by 50-70%,” as the article says.

When President Donald Trump got sick with Covid-19 in October, he credited an antibody drug from Regeneron with making him feel better “immediately.”

“I felt as good three days ago as I do now,” he said in a video shot in front of the White House after he left Walter Reed National Military Medical Center, promising medicines from Regeneron and Eli Lilly would soon be available to the American public to help stop the terrible effects of Covid-19.

The concern, as these drugs were cleared through the FDA and made it to market last month, was that there wouldn’t be enough supply. They’re complicated to manufacture, and Regeneron said there were only enough doses for 80,000 Americans by the end of November. Lilly has 250,000 doses available.

An average of more than 200,000 Americans are currently getting diagnosed with Covid-19 every day, according to data compiled by Johns Hopkins University. Policymakers expected to need to ration the antibody drugs.

But a month into their distribution, the opposite problem has emerged: the drugs are not getting used.

“We have a surplus of these monoclonal antibodies right now,” Health Secretary Alex Azar told CNBC’s Shepard Smith Tuesday night. “What’s happening is people are waiting too long to seek out the treatments.”

Moncef Slaoui, chief scientific adviser to the U.S. government’s Operation Warp Speed, told CNBC Tuesday that the federal government is distributing about 65,000 doses of the antibody drugs every week to states.

But, he said, only 5% to 20% of the doses are getting administered to patients.

“It should be used much more,” Slaoui said in a telephone interview, noting the drugs — which are indicated for patients at high risk for severe Covid-19 — could cut down on hospitalizations by 50% to 70%.

The drugs are not simple to administer. For one thing, they’re given by intravenous infusion, so patients must go to health centers where this can be done. But since they’re likely contagious, existing IV facilities, like where patients receive chemotherapy, can’t be used.

Another issue is that the drugs need to be given early in the course of the disease. The FDA’s guidance for health-care providers says they should be administered as soon as possible after diagnosis, and within 10 days of symptom onset. It recommends against use of the drugs once patients are so sick they’re hospitalized.

But many patients don’t feel sick right away, so the idea of an IV-infused drug doesn’t occur to them immediately after diagnosis, Slaoui and Azar suggested.

“If you are over 65 or at risk of serious complications or hospitalization due to co-morbidities, what have you, and you test positive, you need to seek out and get the Lilly or Regeneron monoclonal antibody,” Azar said on the “News With Shepard Smith.” “It can dramatically reduce the risk for us of hospitalizations at a time when hospitals are getting very crowded with people with Covid.”

But it’s a challenge for some health systems to set up the infrastructure to deliver these drugs. Some states are using 100% of their allocation, Slaoui said. Others, like in Georgia and Illinois, may not be using any, according to former FDA Commissioner Dr. Scott Gottlieb.

Georgia’s public health department didn’t immediately respond to questions about their antibody usage. A spokeswoman for Illinois’ Department of Public Health said providers aren’t yet required to report use of monoclonal antibodies, but that the U.S. Department of Health and Human Services will require hospitals to report the information starting Jan. 8.

[…]

He noted the data behind the medicines suggest “the number needed to treat in terms of keeping one patient out of the hospital … is 10.” Lilly has said it will have 950,000 doses available by the end of January, Gottlieb cited the effects if 900,000 doses were used: “That means if all of the drugs got distributed, we could avoid 90,000 hospitalizations or emergency room visits. That would be substantial.”

Lilly noted the IV administration of the antibody drugs “presents unique challenges to the healthcare system,” and said it’s working to address the challenges to ensure patients who need the drug can get it. The company is running a number of pilot programs through Operation Warp Speed, including one with CVS for in-home infusions, a company spokeswoman said.

Exercising Regularly Strengthens the Immune System

A good thing to keep in mind during a pandemic.

Being in isolation without access to gyms and sports clubs should not mean people stop exercising, according to a new study from researchers at the University of Bath. Keeping up regular, daily exercise at a time when much of the world is going into isolation will play an important role in helping to maintain a healthy immune system.

The analysis, published in the international journal Exercise Immunology Review, involving leading physiologists Dr James Turner and Dr John Campbell from the University of Bath’s Department for Health, considers the effect of exercise on our immune function.

Over the last four decades, many studies have investigated how exercise affects the immune system. It is widely agreed that regular moderate intensity exercise is beneficial for immunity, but a view held by some is that more arduous exercise can suppress immune function, leading to an ‘open-window’ of heightened infection risk in the hours and days following exercise.

In a benchmark study in 2018, this ‘open window’ hypothesis was challenged by Dr Campbell and Dr Turner. They reported in a review article that the theory was not well supported by scientific evidence, summarising that there is limited reliable evidence that exercise suppresses immunity, concluding instead that exercise is beneficial for immune function.

They say that, in the short term, exercise can help the immune system find and deal with pathogens, and in the long term, regular exercise slows down changes that happen to the immune system with ageing, therefore reducing the risk of infections.

Neuroscientists Find Isolation Can Provoke Similar Brain Activity Seen in Hunger

As I heard one commentator say, a pandemic or economic depression by themselves would be problematic, but both together is a much worse problem.

Since the coronavirus pandemic began in the spring, many people have only seen their close friends and loved ones during video calls, if at all. A new study from MIT finds that the longings we feel during this kind of social isolation share a neural basis with the food cravings we feel when hungry.

The researchers found that after one day of total isolation, the sight of people having fun together activates the same brain region that lights up when someone who hasn’t eaten all day sees a picture of a plate of cheesy pasta.

“People who are forced to be isolated crave social interactions similarly to the way a hungry person craves food. Our finding fits the intuitive idea that positive social interactions are a basic human need, and acute loneliness is an aversive state that motivates people to repair what is lacking, similar to hunger,” says Rebecca Saxe, the John W. Jarve Professor of Brain and Cognitive Sciences at MIT, a member of MIT’s McGovern Institute for Brain Research, and the senior author of the study.

The research team collected the data for this study in 2018 and 2019, long before the coronavirus pandemic and resulting lockdowns. Their new findings, described today in Nature Neuroscience, are part of a larger research program focusing on how social stress affects people’s behavior and motivation.

Former MIT postdoc Livia Tomova, who is now a research associate at Cambridge University, is the lead author of the paper. Other authors include Kimberly Wang, a McGovern Institute research associate; Todd Thompson, a McGovern Institute scientist; Atsushi Takahashi, assistant director of the Martinos Imaging Center; Gillian Matthews, a research scientist at the Salk Institute for Biological Studies; and Kay Tye, a professor at the Salk Institute.

Social craving

The new study was partly inspired by a recent paper from Tye, a former member of MIT’s Picower Institute for Learning and Memory. In that 2016 study, she and Matthews, then an MIT postdoc, identified a cluster of neurons in the brains of mice that represent feelings of loneliness and generate a drive for social interaction following isolation. Studies in humans have shown that being deprived of social contact can lead to emotional distress, but the neurological basis of these feelings is not well-known.

“We wanted to see if we could experimentally induce a certain kind of social stress, where we would have control over what the social stress was,” Saxe says. “It’s a stronger intervention of social isolation than anyone had tried before.”

To create that isolation environment, the researchers enlisted healthy volunteers, who were mainly college students, and confined them to a windowless room on MIT’s campus for 10 hours. They were not allowed to use their phones, but the room did have a computer that they could use to contact the researchers if necessary.

“There were a whole bunch of interventions we used to make sure that it would really feel strange and different and isolated,” Saxe says. “They had to let us know when they were going to the bathroom so we could make sure it was empty. We delivered food to the door and then texted them when it was there so they could go get it. They really were not allowed to see people.”

After the 10-hour isolation ended, each participant was scanned in an MRI machine. This posed additional challenges, as the researchers wanted to avoid any social contact during the scanning. Before the isolation period began, each subject was trained on how to get into the machine, so that they could do it by themselves, without any help from the researcher.

“Normally, getting somebody into an MRI machine is actually a really social process. We engage in all kinds of social interactions to make sure people understand what we’re asking them, that they feel safe, that they know we’re there,” Saxe says. “In this case, the subjects had to do it all by themselves, while the researcher, who was gowned and masked, just stood silently by and watched.”

Each of the 40 participants also underwent 10 hours of fasting, on a different day. After the 10-hour period of isolation or fasting, the participants were scanned while looking at images of food, images of people interacting, and neutral images such as flowers. The researchers focused on a part of the brain called the substantia nigra, a tiny structure located in the midbrain, which has previously been linked with hunger cravings and drug cravings. The substantia nigra is also believed to share evolutionary origins with a brain region in mice called the dorsal raphe nucleus, which is the area that Tye’s lab showed was active following social isolation in their 2016 study.

The researchers hypothesized that when socially isolated subjects saw photos of people enjoying social interactions, the “craving signal” in their substantia nigra would be similar to the signal produced when they saw pictures of food after fasting. This was indeed the case. Furthermore, the amount of activation in the substantia nigra was correlated with how strongly the patients rated their feelings of craving either food or social interaction.

Degrees of loneliness

The researchers also found that people’s responses to isolation varied depending on their normal levels of loneliness. People who reported feeling chronically isolated months before the study was done showed weaker cravings for social interaction after the 10-hour isolation period than people who reported a richer social life.

“For people who reported that their lives were really full of satisfying social interactions, this intervention had a bigger effect on their brains and on their self-reports,” Saxe says.

The researchers also looked at activation patterns in other parts of the brain, including the striatum and the cortex, and found that hunger and isolation each activated distinct areas of those regions. That suggests that those areas are more specialized to respond to different types of longings, while the substantia nigra produces a more general signal representing a variety of cravings.

Now that the researchers have established that they can observe the effects of social isolation on brain activity, Saxe says they can now try to answer many additional questions. Those questions include how social isolation affect people’s behavior, whether virtual social contacts such as video calls help to alleviate cravings for social interaction, and how isolation affects different age groups.

The researchers also hope to study whether the brain responses that they saw in this study could be used to predict how the same participants responded to being isolated during the lockdowns imposed during the early stages of the coronavirus pandemic.

The research was funded by a SFARI Explorer Grant from the Simons Foundation, a MINT grant from the McGovern Institute, the National Institutes of Health, including an NIH Pioneer Award, a Max Kade Foundation Fellowship, and an Erwin Schroedinger Fellowship from the Austrian Science Fund.

U.S. Hospitals Charging Patients Up to 1800% More for Services Than They Cost

The American system has produced some incredible medical advances, but it is reasons like these absurdly high costs that make it largely such a catastrophe.

Hospitals in the United States charge patients as much as 1,800% more than their costs amid the coronavirus pandemic, according to a new study.

The 100 most expensive hospitals in the United States charge between $1,129 and $1,808 for every $100 of their costs, according to a study by National Nurses United, the largest nurses union in the country.

Overall, hospitals across the US charge an average of $417 for every $100 of their costs. The average markup has more than doubled over the past two decades, according to the report.

The markups have resulted in hospital profits skyrocketing by 411% from 1999 to 2017, hitting a record $88 billion.

“The rise in charges coincides with growing hospital mergers and acquisitions by large systems,” the union said in a news release. “The result is increased market consolidation, which leads to higher profits and increased charges, not savings for patients as hospital systems often claim.”

Medical workers worry that high costs will increase the number of people avoiding medical care.

“There is no excuse for these scandalous prices. These are not markups for luxury condo views, they are for the most basic necessity of your life: your health,” nurse Jean Ross, the president of the union, said in a statement. “Unpayable charges are a calamity for our patients, too many of whom avoid— at great risk to their health — the medical care they need due to the high cost, or they become burdened by devastating debt, hounded by bill collectors or driven into bankruptcy.”

The union warned that “high hospital charges also drive up Covid-19 treatment costs.”

A study by the health care data nonprofit FAIR Health in the spring found that uninsured coronavirus patients or those that receive care considered out-of-network by their insurer face costs ranging from $42,486 to $74,310 if they require inpatient hospital treatment.

A survey by the health care research group the Commonwealth Fund also found that more than two-thirds of Americans say that “potential out-of-pocket costs would be very or somewhat important in their decision to seek care if they had symptoms of the coronavirus.”

While insurers often negotiate prices with hospitals, uninsured patients have little recourse. And as with other health care and coronavirus-related disparities, people of color are disproportionately impacted. Latinos are nearly three times as likely and Black people are nearly twice as likely to be uninsured than white Americans, according to a study from the Kaiser Family Foundation.

The National Nurses United report argued that the findings further make the case for a Medicare for All system because Medicare is the “most effective” system to limit price gouging.

“The most viable solution to slowing the growth in hospital charges and the continued inflation of hospital prices, is to bring all health care purchasers together, under a public, nationwide single-payer plan,” the report said.

The RAND Corporation, a nonprofit think tank, found that hospitals charged private insurers an average of 2.4 times more than Medicare rates.

“Nurses know that the best way to rein in these outrageous charges that create such grievous harm for our patients is with Medicare for All, as other countries have proven,” said Ross, the union president. “Medicare for All will not only guarantee health care coverage for every person in the United States, it will end medical bankruptcies, medical debt lawsuits, and the health insecurity faced by millions who make painful choices every day about whether to seek the care they desperately need.”

[…]

A study published in the Annals of Internal Medicine earlier this year found that 34% of health care expenditures go toward administrative costs alone. The US spent about $2,497 per person on administrative costs in 2017, compared to $551 per person in Canada, which has a single-payer system. Switching to a single-payer system would drive down health care costs by $600 billion on administrative costs alone, according to the analysis.

“Americans spend twice as much per person as Canadians on health care. But instead of buying better care, that extra spending buys us sky-high profits and useless paperwork,” lead author Dr. David Himmelstein, a professor at the CUNY School of Public Health at Hunter College, said in a statement.

Another study published in The Lancet earlier this year found that Medicare for All would save the country about $450 billion per year while preventing more than 68,000 unnecessary deaths annually.

Lead researcher Dr. Alison Galvani, an epidemiologist and director of the Center for Infectious Disease Modeling and Analysis at Yale University, argued that Biden’s proposal to essentially expand Obamacare could actually increase costs compared to the Medicare for All plan that the president-elect decried during the primaries as too costly.

“Without the savings to overhead, pharmaceutical costs, hospital/clinical fees, and fraud detection, ‘Medicare for all who want it’ could annually cost $175 billion dollars more than status quo,” she told Newsweek. “That’s over $600 billion more than Medicare for all.”

An analysis published in PLOS Medicine of 22 single-payer studies showed that 19 of them “predicted net savings … in the first year of program operation and 20 … predicted savings over several years; anticipated growth rates would result in long-term net savings for all plans.”

Critics have argued that reducing costs by switching to a single-payer system would result in doctor shortages and the rationing of health care. But data shows that fewer than 1% of doctors have opted out of the existing Medicare and Medicaid programs, with nearly half of those being psychiatrists. Single-payer proponents also dismiss rationing claims, arguing that Americans are already effectively self-rationing due to sky-high costs, even for those with private insurance.

A Federal Reserve survey published last year found that about 25% of American “adults skipped necessary medical care in 2018 because they were unable to afford the cost.” Another survey found that 26% of Americans with diabetes have rationed their insulin, primarily due to the cost.

“It would be a missed opportunity for America to ignore lessons about universal coverage from other countries out of a fear that they ration health care more than we do,” researchers at the Commonwealth Fund warned in a report last year. “In reality, more people in the U.S. forgo needed health care because access to care is rationed through lack of access to adequate insurance or unaffordable services and treatments.”

Honey Has Been Shown to Treat Upper Respiratory Infections Better Than Traditional Remedies

Honey is unique in that its a bacteria-killing agent that hasn’t been shown to trigger antibiotic resistance due to how it naturally contains hydrogen peroxide.

A trio of researchers at Oxford University has found that honey is a better treatment for upper respiratory tract infections (URTIs) than traditional remedies. In their paper published in BMJ Evidence-based Medicine, Hibatullah Abuelgasim, Charlotte Albury, and Joseph Lee describe their study of the results of multiple clinical trials that involved testing of treatments for upper respiratory tract infections (URTIs) and what they learned from the data.

Over the past several years, the medical community has grown alarmed as bacteria have developed resistance to antibacterial agents. Some studies have found that over-prescription of such remedies is hastening the pace. Of particular concern are antibacterial prescriptions written for maladies that they are not likely to help, simply due to demands from patients. One such case is often URTIs, the vast majority of which are caused by viruses, not bacteria. Because of such cases, scientists have been looking for other remedies for these infections, and one therapy in particular has begun to stand out: honey.

Anecdotal evidence has suggested that honey can be used to treat colds in general and coughs in particular—people have been using it as a therapy for thousands of years. In this new effort, the researchers looked at the results of multiple clinical trials testing the effectiveness of therapies against URTIs. In all, the team looked at data from 14 clinical trials involving 1,761 patients.

In analyzing the data from all of the trials combined, the researchers found that the trials had included studies of virtually all of the traditional remedies such as over-the-counter cold and sinus medicines as well as antibiotics—and honey. They found that honey proved to be the best therapy among all of those tested. In addition to proving more effective in treating coughing (36 percent better at reducing the amount of coughing and 44 percent better at reducing coughing severity), it also led to a reduction in average duration of infection by two days.

The researchers note that the reason honey works as a treatment for URTIs is because it contains hydrogen peroxide—a known bacteria killer—which also makes it useful as a topical treatment for cuts and scrapes. Honey is also of the right consistency—its thickness works to coat the mouth and throat, soothing irritation.

Hangover Cure Found by Finland Researchers

This seems to be the most legitimate research done on a compound (amino acid L-cysteine) that will remove symptoms of an alcohol-induced hangover. The consumption of alcohol weakens the immune system and therefore might be something people might not want to have during a global pandemic, but if people do choose to consume alcohol, L-cysteine is relatively cheap to buy and (unlike many other remedies) has clinical data to support its efficacy.

Hangover Cure Successfully Tested on Drunk Subjects in Finland

A dose of 1,200 milligrams of amino acid L-cysteine was found to reduce alcohol-related nausea and headache, while a dose of 600 milligrams helped alleviate stress and anxiety, according to a study published in the journal Alcohol and Alcoholism by researchers at the University of Helsinki and the University of Eastern Finland.

The randomized, double-blind study had 19 healthy male volunteers consuming alcohol doses of 1.5 grams per kilogram over three hours in a controlled setting. The subjects were then asked to swallow placebo or L-cysteine tablets containing vitamin supplements.

Researchers say that as well as reducing or even eliminating hangovers entirely, L-cysteine also helps “reduce the need of drinking the next day,” thereby cutting the risk of alcohol addiction.

Binge drinking is common in Finland, with more than half a million Finns considered at risk from excessive drinking.

The researchers received funding from Catapult Cat Oy, which sells the L-cysteine supplements.

The study ran into certain difficulties. Some participants weren’t able to consume all the alcohol required and had to be excluded, some had such high tolerance levels that they experienced no hangover symptoms; and some were sidelined because they insisted on topping up the dose by heading for the bar, researcher Markus Metsala told local media.

U.S. Drinking Water Contamination Far Worse Than Previously Thought

Dark humor comedian George Carlin liked to say that he didn’t consider himself a good American if he didn’t let his food and water poison himself a bit every day. For real though, if you want at least some defense against the contamination, the people in the know recommend robust water filtration systems.

America is great again! Keep this version of America great 2020, don’t change it! Only over a hundred million people there drink contaminated water every day!

The contamination of US drinking water with manmade “forever chemicals” is far worse than previously estimated with some of the highest levels found in Miami, Philadelphia and New Orleans, said a report on Wednesday by an environmental watchdog group.

The chemicals, resistant to breaking down in the environment, are known as perfluoroalkyl substances, or PFAS. Some have been linked to cancers, liver damage, low birth weight and other health problems.

The findings here by the Environmental Working Group (EWG) show the group’s previous estimate in 2018, based on unpublished US Environmental Protection Agency (EPA) data, that 110 million Americans may be contaminated with PFAS, could be far too low.

“It’s nearly impossible to avoid contaminated drinking water from these chemicals,” said David Andrews, a senior scientist at EWG and co-author of the report.

The chemicals were used in products like Teflon and Scotchguard and in firefighting foam. Some are used in a variety of other products and industrial processes, and their replacements also pose risks.

Of tap water samples taken by EWG from 44 sites in 31 states and Washington DC, only one location, Meridian, Mississippi, which relies on 700ft (215m) deep wells, had no detectable PFAS. Only Seattle and Tuscaloosa, Alabama had levels below 1 part per trillion (PPT), the limit EWG recommends.

In addition, EWG found that on average six to seven PFAS compounds were found at the tested sites, and the effects on health of the mixtures are little understood. “Everyone’s really exposed to a toxic soup of these PFAS chemicals,” Andrews said.

In 34 places where EWG’s tests found PFAS, contamination had not been publicly reported by the EPA or state environmental agencies.

The EPA has known since at least 2001 about the problem of PFAS in drinking water but has so far failed to set an enforceable, nationwide legal limit. The EPA said early last year it would begin the process to set limits on two of the chemicals, PFOA and PFOS.

The EPA said it has helped states and communities address PFAS and that it is working to put limits on the two main chemicals but did not give a timeline.

In 2018 a draft report from an office of the US Department of Health and Human Services said the risk level for exposure to the chemicals should be up to 10 times lower than the 70 PPT threshold the EPA recommends. The White House and the EPA had tried to stop the report from being published.

How Toxic Chemicals Are Robbing Vulnerable Children of Millions of IQ Points

The crisis of contaminated water seen in Flint, Michigan is ongoing and terrible, but other related events of contamination are more common than people tend to think they are. America is a society with many protections for the most powerful, and not enough for the most vulnerable.

The chemicals we’ve long feared the most – heavy metals like lead and mercury – are less of a threat to kids’ developing brains than they were two decades ago. But two new menaces may be taking their place: pesticides and flame retardants.

According to new research from New York University, flame retardants resulted in a loss of 162 million IQ points among children in the US between 2001 and 2016.

The study, published Tuesday in the journal Molecular and Cellular Endocrinology, looked at the four chemicals known to impact the brain of a developing child most: lead, mercury, pesticides, and polybrominated diphenyl ethers (otherwise known as flame retardants).

Leo Trasande, a paediatrician and public-health researcher at NYU who co-authored the study, described these pollutants as “hit-and-run” chemicals: Once a child is exposed to them, there’s no reversing the damage.

“Kids’ brain development is exquisitely vulnerable,” Trasande told Business Insider. “If you disrupt, even with subtle effects, the way a child’s brain is wired, you can have permanent and lifelong consequences.”

The study found that lead cost US kids 78 million IQ points during the 15-year period studied, while pesticides caused a loss of nearly 27 million IQ points during those years. Mercury, meanwhile, caused a loss of 2.5 million IQ points.

Children’s’ lower IQs are costing the US trillions of dollars

The researchers found that among kids exposed to toxins from 2001 to to 2016, the proportion of IQ loss due to exposure to flame retardants and pesticides increased from 67 percent to 81 percent. Flame retardants can be found in household furniture and electronics, while pesticides can be consumed when they linger on produce.

“What we found was quite striking,” Trasande said.

“We know that there is no safe level of lead exposure. The same is true for methylmercury, pesticides, and flame retardants.”

The study also found that there is an economic cost to childhood brain damage: Trasande said that each individual IQ point is worth roughly 2 percent of a child’s lifetime economic productivity. So if a child could potentially make US$1 million over the course of their lifetime, they would lose US$20,000 for every IQ point lost.

“A kid’s brain power is the engine of our economy,” Trasande said.

“If a child comes back from school with one less IQ point, maybe mum or the parent might not notice. But if 100,000 children come back with one less IQ point, the entire economy notices.”

According to the researchers, IQ loss due to lead, mercury, flame retardants, and pesticide exposure combined cost the US around US$6 trillion from 2001 to 2016.

Regulations on flame retardants and pesticides are more lax than heavy metals

For decades, scientists have understood that exposure to lead and mercury can result in childhood brain damage. So many of the main hideouts for these chemicals – leaded gasoline, lead paint, and mercury emissions from coal-fired power plants – have been phased out.

As early as the 1970s, the Environmental Protection Agency required lead to be phased out of gasoline and paint (though lead paint can still be found in homes built before 1978).

The agency also set standards to reduce mercury emissions from coal-fired power plants in 2011, though some power plants still do not meet these requirements.

But there have been fewer efforts to regulate pesticides and flame retardants.

The EPA has banned around 37 pesticides, though more than 500 have been used in the US. Another 97 have been voluntarily withdrawn by pesticide manufacturers.

More than a dozen states have adopted legislation that restricts the use of flame retardants in products like furniture, carpeting, and children’s toys, but none of the chemicals are banned federally.

Ways to reduce kids’ exposure

Many factors can influence a kid’s exposure to a chemical, Transande said.

“The science has really evolved such that the dose is not the only thing that makes the poison,” he said. Other factors to consider could include the timing and frequency of exposure.

Trasande added that regulating all of these chemicals has a far lower long-term economic cost than the cost of kids’ lost IQ points due to exposure.

To minimise personal risk in one’s own home, Trasande suggested simple steps like opening windows so that dust laced with flame retardants can escape. He also suggested vacuuming frequently and using a wet mop to sop up chemicals on the floor.

In addition, parents should avoid mattresses and children’s toys that contain polyurethane foam (which often carries flame retardants).

Trasande also said households should avoid spraying pesticides on their lawns or backyards and recommended switching to organic foods (though organic produce can also contain pesticides).

“We’ve made less progress in phasing out or banning some of the pesticides of greatest concern,” Trasande said. “But there are steps we can take proactively as consumers.”

Major Benefits of Reducing Air Pollution

Air pollution has for many years been a major public health problem that doesn’t receive much attention despite its significant effects on the population. It has been estimated that the majority of people in the world are regularly breathing unclean air.

Reductions in air pollution yielded fast and dramatic impacts on health-outcomes, as well as decreases in all-cause morbidity, according to findings in “Health Benefits of Air Pollution Reduction,” new research published in the American Thoracic Society’s journal, Annals of the American Thoracic Society.

The study by the Environmental Committee of the Forum of International Respiratory Societies (FIRS) reviewed interventions that have reduced air pollution at its source. It looked for outcomes and time to achieve those outcomes in several settings, finding that the improvements in health were striking. Starting at week one of a ban on smoking in Ireland, for example, there was a 13 percent drop in all-cause mortality, a 26 percent reduction in ischemic heart disease, a 32 percent reduction in stroke, and a 38 percent reduction in chronic obstructive pulmonary disease (COPD). Interestingly, the greatest benefits in that case occurred among non-smokers.

“We knew there were benefits from pollution control, but the magnitude and relatively short time duration to accomplish them were impressive,” said lead author of the report, Dean Schraufnagel, MD, ATSF. “Our findings indicate almost immediate and substantial effects on health outcomes followed reduced exposure to air pollution. It’s critical that governments adopt and enforce WHO guidelines for air pollution immediately.”

In the United States, a 13-month closure of a steel mill in Utah resulted in reducing hospitalizations for pneumonia, pleurisy, bronchitis and asthma by half. School absenteeism decreased by 40 percent, and daily mortality fell by 16 percent for every 100 ?g/m3 PM10 (a pollutant) decrease. Women who were pregnant during the mill closing were less likely to have premature births.

A 17-day “transportation strategy,” in Atlanta, Georgia during the 1996 Olympic Games involved closing parts of the city to help athletes make it to their events on time, but also greatly decreased air pollution. In the following four weeks, children’s visits for asthma to clinics dropped by more than 40 percent and trips to emergency departments by 11 percent. Hospitalizations for asthma decreased by 19 percent. Similarly, when China imposed factory and travel restrictions for the Beijing Olympics, lung function improved within two months, with fewer asthma-related physician visits and less cardiovascular mortality.

In addition to city-wide polices, reducing air pollution within the home also led to health benefits. In Nigeria, families who had clean cook stoves that reduced indoor air pollution during a nine-month pregnancy term saw higher birthweights, greater gestational age at delivery, and less perinatal mortality.

The report also examines the impact of environmental policies economically. It highlights that 25 years after enactment of the Clean Air Act, the U.S. EPA estimated that the health benefits exceeded the cost by 32:1, saving 2 trillion dollars, and has been heralded as one of the most effective public health policies of all time in the United States. Emissions of the major pollutants (particulate matter [PM], sulfur oxides, nitrogen oxides, carbon monoxide, volatile organic compounds, and lead) were reduced by 73 percent between 1990 and 2015 while the U.S. gross domestic product grew by more than 250 percent.

Given these findings, Dr. Schraufnagel has hope. “Air pollution is largely an avoidable health risk that affects everyone. Urban growth, expanding industrialization, global warming, and new knowledge of the harm of air pollution raise the degree of urgency for pollution control and stress the consequences of inaction,” he says. “Fortunately, reducing air pollution can result in prompt and substantial health gains. Sweeping policies affecting a whole country can reduce all-cause mortality within weeks. Local programs, such as reducing traffic, have also promptly improved many health measures.”

Abortion Reversal — The Dangerous Practice You’ve Probably Never Heard Of

In the United States, many more laws have been implemented that restrict or ban a woman’s ability to have an abortion. Abortion reversal is a new technique that hasn’t undergone much medical testing since the one test on it showed significant harm to the women.

Several states now require women who seek medication abortions to be provided with dubious information that the procedure could be stopped, allowing a pregnancy to continue.

But when researchers attempted to carry out a legitimate study of whether these “abortion reversal” treatments were effective and safe, they had to stop almost immediately – because some of the women who participated in the study experienced dangerous hemorrhaging that sent them to the hospital.

By passing these abortion reversal laws, “states are encouraging women to participate in an unmonitored experiment,” Creinin said.

Creinin and his colleagues detailed their concerns in a commentary in the journal Contraception, and they will publish their study in January’s edition of Obstetrics and Gynecology.

Medication abortions, which are used up to 10 weeks into a pregnancy, consist of taking two pills in sequence. The first pill in the regimen, mifepristone, loosens the pregnancy’s attachment to the uterus. The second pill, misoprostol, forces the uterus to contract to push out the pregnancy. The pills must be taken consecutively to complete the abortion, and there’s a chance the pregnancy will continue if the second pill is not taken.

A total of 862,320 abortions were provided in clinical settings in 2017, according to the Guttmacher Institute, about 39 percent of which were medication abortions. Research has shown that using these drugs is a safe way to end a pregnancy.

Some antiabortion activists and legislators claim that not taking the second pill, or giving a woman high doses of the hormone progesterone after taking mifepristone, can help stop, or “reverse,” a medical abortion.

The American College of Obstetricians and Gynecologists firmly states that “claims regarding abortion ‘reversal’ treatment are not based on science and do not meet clinical standards” and say the purported studies that underpin these antiabortion arguments lack scientific rigor and ethics.

Despite this, the claims made in these discredited studies have worked their way to antiabortion lawmakers, who in turn have put them into abortion reversal legislation that was signed by governors in North Dakota, Idaho, Utah, South Dakota, Kentucky, NebraskaOklahoma and Arkansas. The laws are currently blocked or enjoined in Oklahoma and North Dakota.

Because reliable research on these treatments is nonexistent, earlier this year, Creinin and his colleagues designed a legitimate double-blind, placebo-controlled, randomized trial that aimed to observe 40 volunteers who had already elected to have a surgical abortion.

Their goal was to see if giving progesterone to women who took the first pill in the prescribed regimen would effectively and safely halt an abortion.

After the women took the first pill in the abortion protocol, mifepristone, rather than take the second pill, misoprostol, they were either given a placebo or a dose of progesterone.

Researchers only enrolled 12 women before they had to stop the study.

Bleeding is normal during a medication abortion. But three of the women who enrolled in the UC-Davis study experienced far more serious bleeding than anyone could have anticipated when the second pill was not administered.

One woman “was so scared she called an ambulance,” while another woman startled by the amount of blood “called 911 and crawled into her bathtub”, Creinin said. A third woman who went to the emergency room needed a transfusion. One of the women had received a placebo, while two others had taken the progesterone.

Creinin and his colleagues halted the study as soon as it became clear that they could not proceed safely.

“I feel really horrible that I couldn’t finish the study. I feel really horrible that the women … had to go through all this,” Creinin said. Because the study ended prematurely, the researchers could not establish any evidence that progesterone was an effective way to stop a medication abortion.

“What the results do show, though, is that there’s a very significant safety signal” when it comes to disrupting the approved medication abortion protocol, Creinin said.

In their upcoming paper in Obstetrics and Gynecology, the researchers warn that “patients in early pregnancy who use only mifepristone may be at high risk of significant hemorrhage.”

Medical experts are so concerned about abortion reversal laws that the American Medical Association joined a lawsuit against North Dakota’s abortion reversal law, which was blocked by a federal judge in September.

The North Dakota abortion reversal law, signed by Gov. Doug Burgum (R) in March, instructed health-care providers to tell a woman “that it may be possible to reverse the effects of an abortion-inducing drug if she changes her mind, but time is of the essence” and to provide a woman with literature on how to do this. The law fails to specify what that literature would include, or what such a treatment might entail.