Experimental Electric Therapy to Treat Mental Health Problems is Curing PTSD

This is unique research, although it is difficult to determine how valuable it is or its potential for misuse, but its potential of treating mental health disorders — an immense problem in modern society — makes it worth mentioning.

Hundreds of vets have tried out an experimental new treatment that could change how the world addresses mental disorders.

Tony didn’t know what to expect when he walked into the Brain Treatment Center in San Diego, California, last spring. The former Navy SEAL only knew that he needed help. His service in Iraq and Afghanistan was taking a heavy toll on his mental and physical wellbeing. He had trouble concentrating, remembering, and was given to explosive bursts of anger. “If somebody cut me off driving, I was ready to kill ’em at the drop of a hat,” he said. And after he got into a fistfight on the side of a California road, his son looking on from the car, he decided he was willing to try anything — even an experimental therapy that created an electromagnetic field around his brain.

What Tony and several other former U.S. Special Operations Forces personnel received Newport Brain Research Laboratory, located at the Center, was a new treatment for brain disorders, one that might just revolutionize brain-based medicine. Though the FDA clinical trials to judge its efficacy and risks are ongoing, the technique could help humanity deal with a constellation of its most common mental disorders — depression, anxiety, aggressiveness, attention deficit, and others—and do so without drugs. And if its underpinning theory proves correct, it could be among the biggest breakthroughs in the treatment of mental health since the invention of the EEG a century ago.

At the lab, Tony (whose name has been changed to protect his identity) met Dr. Erik Won, president and CEO of the Newport Brain Research Laboratory, the company that’s innovating Magnetic EEG/ECG-guided Resonant Therapy, or MeRT. Won’s team strapped cardiac sensors on Tony and placed an electroencephalography cap on his skull to measure his brain’s baseline electrical activity. Then came the actual therapy. Placing a flashlight-sized device by Tony’s skull, they induced an electromagnetic field that senta small burst of current to his brain. Over the course of 20 minutes, they moved the device around his cranium, delivering jolts that, at their most aggressive, felt like a firm finger tapping.

For Tony, MeRT’s effects were obvious and immediate. He walked out of the first session to a world made new. “Everything looked different,” he told me. “My bike looked super shiny.”

He began to receive MeRT five times a week— each session lasting about an hour, with waiting room time — and quickly noticed a change in his energy. “I was super boosted,” he said. His mood changed as well.

Today, he admits that he still has moments of frustration but says that anger is no longer his “go-to emotion.” He’s developed the ability to cope. He still wants help with his memory, but his life is very different. He’s taken up abstract painting and welding, two hobbies he had no interest in at all before the therapy. He’s put in a new kitchen. Most importantly, his sleep is very different: better.

Tony’s experience was similar to those of five other special-operations veterans who spoke with Defense One. All took part in a double-blind randomized clinical trial that sought to determine how well MeRT treats Persistent Post-Concussion Symptoms and Post-Traumatic Stress Disorder, or PTSD. Five out of the six were former Navy SEALS.

[…]

All said that they saw big improvements after a course of therapy that ran five days a week for about four weeks. Bill reported that his headaches were gone, as did Cathy, who said her depression and mood disorders had lessened considerably. Jim’s memory and concentration improved so dramatically that he had begun pursuing a second master’s degree and won a spot on his college’s football team. Ted said he was feeling “20 years younger” physically and found himself better able to keep pace with the younger SEALS he was training. All of it, they say, was a result of small, precisely delivered, pops of electricity to the brain. Jim said the lab had also successfully treated back and limb pain by targeting the peripheral nervous system with the same technique.

[…]

The lab is about one-third of the way through a double-blind clinical trial that may lead to FDA approval, and so Won was guarded in what he could say about the results of their internal studies. But he said that his team had conducted a separate randomized trial on 86 veterans. After two weeks, 40 percent saw changes in their symptoms; after four weeks, 60 did, he said.

“It’s certainly not a panacea,” said Won. “There are people with residual symptoms, people that struggle…I would say the responses are across the board. Some sleep better. Some would say, very transformative.” (Won doesn’t even categorize the treatment as “curing,” as that has a very specific meaning in neurology and mental health, so much as “helping to treat.”)

[…]

The separate notion that electricity could be used to treat mental disorder entered wide medical practice with the invention of electroconvulsive therapy, or ECT, in Italy in the 1930s. ECT — more commonly called shock therapy — used electricity to induce a seizure in the patient. Its use spread rapidly across psychiatry as it seemed to not only meliorate depression but also to temporarily pacify patients who suffered from psychosis and other disorders. Before long, doctors in mental institutions were prescribing it commonly to subdue troublesome patiets and even as a “cure” for homosexuality. The practice soon became associated with institutional cruelty.

In the 1990s, a handful of researchers, independent of another, realized that electricity at much lower voltages could be used to help with motor function in Parkinson’s patients and as an aid for depression. But there was a big difference between their work and that of earlier practitioners of ECT: they used magnetic fields rather than jolts of electricity. This allowed them to activate brain regions without sending high currents through the skull. Seizures, it seemed, weren’t necessary.

In 2008, researchers began to experiment with what was then called transcranial magnetic stimulation to treat PTSD. Since then, it’s been approved as a treatment for depression. Won and his colleagues don’t use it in the same way that doctors do when they’re looking for something simple and easy to spot, like potential signs of a seizure or head trauma. Won uses EEG/ECG biometrics to find the subject’s baseline frequency, essentially the “normal” state to return her or him to, and also to precisely target the areas of the brain that will respond to stimulation in the right way.

YOU Have a Signature. Your Signature is YOU

No two people experience mental health disorders in the same way. Some PTSD sufferers have memory problems; others, depression; still others, uncontrollable anger. But people that are diagnosed with depression are more likely to suffer from another, separate mental health issue, such as anxiety, attention deficit, or something else.

The theory that underpins MeRT posits that many of these problems share a common origin: a person’s brain has lost the beat of its natural information-processing rhythm, what Won calls the “dominant frequency.”

Your dominant frequency is how many times per second your brain pulses alpha waves. “We’re all somewhere between 8 and 13 hertz. What that means is that we encode information 8 to 13 times per second. You’re born with a signature. There are pros and cons to all of those. If you’re a slower thinker, you might be more creative. If you’re faster, you might be a better athlete,” Won says.

Navy SEALS tend to have higher-than-average dominant frequencis, around 11 or 13 Hz. But physical and emotional trauma can disrupt that, causing the back of the brain and the front of the brain to emit electricity at different rates. The result: lopsided brain activity. MeRT seeks to detect arrhythmia, find out which regions are causing it, and nudge the off-kilter ones back onto the beat.

“Let’s just say in the left dorsal lateral prefrontal cortex, towards the front left side of the brain, if that’s cycling at 2 hertz, where we are 3 or 4 standard deviations below normal, you can pretty comfortably point to that and say that these neurons aren’t firing correctly. If we target that area and say, ‘We are going to nudge that area back to, say, 11 hertz,’ some of those symptoms may improve,” says Won. “In the converse scenario, in the right occipital parietal lobe where, if you’ve taken a hit, you may be cycling too fast. Let’s say it’s 30 hertz. You’re taking in too much information, oversampling your environment. And if you’re only able to process it using executive function 11 times per second, that information overload might manifest as anxiety.”

If the theory behind MeRT is true, it could explain, at least partially, why a person may suffer from many mental-health symptoms: anxiety, depression, attention deficits, etc. The pharmaceutical industry treats them with separate drugs, but they all may have a similar cause, and thus be treatable with one treatment. That, anyway, is what Won’s preliminary results are suggesting.

“You don’t see these type of outcomes with psychopharma or these other types of modalities, so it was pretty exciting,” he said.

There are lots of transcranial direct stimulation therapies out there, with few results to boast of. What distinguishes MeRT from other attempts to treat mental disorders with electrical fields is the use of EEG as a guide. It’s the difference between trying to fix something with the aid of a manual versus just winging it.

If the clinical trials bear out and the FDA approves of MeRT as an effective treatment for concussion and/or PTSD, many more people will try it. The dataset will grow, furthering the science. If that happens, the world will soon know whether or not there is a better therapeutic for mood and sleep disorders than drugs; and a huge portion of the pharmaceutical industry will wake up to earth-changing news.

But there’s more. Won believes that MeRT may have uses for nominally healthy brains, such as improving attention, memory, and reaction time, as Ted discovered. It’s like the eyesight thing, the sudden, stark visual clarity. “These were unexpected findings, but we’re hearing it enough that we want to do more studies.”

Performance enhancement is “not something that we’re ardently chasing,” says Won. ”Our core team is about saving lives. But so many of our veterans are coming back asking.”

Already, there’s evidence to suggest that it could work. “What we’ve noticed in computerized neuro-psych batteries is that reaction times improve. Complex cognitive processing tasks can improve both in terms of speed to decision and the number of times you are right versus wrong. Those are all things we want to quantify and measure with good science,” he says.

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New Bandage Speeds Skin Healing By Using Electric Stimulation

It’s cool that the bandage worked well on rats (which are used in scientific experiments due to having some important similarities to humans) by using electric stimulation created by an electric field.

Skin has a remarkable ability to heal itself. But in some cases, wounds heal very slowly or not at all, putting a person at risk for chronic pain, infection and scarring. Now, researchers have developed a self-powered bandage that generates an electric field over an injury, dramatically reducing the healing time for skin wounds in rats. They report their results in ACS Nano.

Chronic skin wounds include diabetic foot ulcers, venous ulcers and non-healing surgical wounds. Doctors have tried various approaches to help chronic wounds heal, including bandaging, dressing, exposure to oxygen and growth-factor therapy, but they often show limited effectiveness. As early as the 1960s, researchers observed that electrical stimulation could help skin wounds heal. However, the equipment for generating the electric field is often large and may require patient hospitalization. Weibo Cai, Xudong Wang and colleagues wanted to develop a flexible, self-powered bandage that could convert skin movements into a therapeutic electric field.

To power their electric bandage, or e-bandage, the researchers made a wearable nanogenerator by overlapping sheets of polytetrafluoroethylene (PTFE), copper foil and polyethylene terephthalate (PET). The nanogenerator converted skin movements, which occur during normal activity or even breathing, into small electrical pulses. This current flowed to two working electrodes that were placed on either side of the skin wound to produce a weak electric field. The team tested the device by placing it over wounds on rats’ backs. Wounds covered by e-bandages closed within 3 days, compared with 12 days for a control bandage with no electric field. The researchers attribute the faster wound healing to enhanced fibroblast migration, proliferation and differentiation induced by the electric field.

Negative Energy Pricing Becoming More Common as Clean Energy Outdoes Fossil Fuels

Imagine living in a world where one of the most significant threats in the decades ahead is for the most part not being properly addressed, and is in many ways being exacerbated. The threat is climate change, and for one thing, it’s being exacerbated by having massive fossil fuel subsidies instead of massive clean energy subsidies. This is of course despite clean energy already regularly outcompeting fossil fuels.

Bright and breezy days are becoming a deeper nightmare for utilities struggling to earn a return on traditional power plants.

With wind and solar farms sprouting up in more areas — and their power getting priority to feed into the grid in many places — the amount of electricity being generated is outstripping demand during certain hours of the day.

The result: power prices are slipping to zero or even below more often in more jurisdictions.

[…]

Periods with negative prices occur when there is more supply than demand, typically during a mid-day sun burst or early morning wind gust when demand is already low. A negative price is essentially a market signal telling utilities to shut down certain power plants. It doesn’t result in anyone getting a refund on bills — or in electric meters running backward.

Instead, it often prompts owners of traditional coal and gas plants to shut down production for a period even though many of the facilities aren’t designed to switch on and off quickly. It’s left the utilities complaining that they can’t earn the returns they expected for their investment in generation capacity.

First Electrified Road for Charging Vehicles is Now Open in Sweden

An amazing innovation that should be deployed much more broadly to drastically reduce dependence on fossil fuels.

The world’s first electrified road that recharges the batteries of cars and trucks driving on it has been opened in Sweden.

About 2km (1.2 miles) of electric rail has been embedded in a public road near Stockholm, but the government’s roads agency has already drafted a national map for future expansion.

Sweden’s target of achieving independence from fossil fuel by 2030 requires a 70% reduction in the transport sector.

The technology behind the electrification of the road linking Stockholm Arlanda airport to a logistics site outside the capital city aims to solve the thorny problems of keeping electric vehicles charged, and the manufacture of their batteries affordable.

Energy is transferred from two tracks of rail in the road via a movable arm attached to the bottom of a vehicle. The design is not dissimilar to that of a Scalextric track, although should the vehicle overtake, the arm is automatically disconnected.

Hans Säll, chief executive of the eRoadArlanda consortium behind the project, said both current vehicles and roadways could be adapted to take advantage of the technology.

In Sweden there are roughly half a million kilometres of roadway, of which 20,000km are highways, Säll said.

“If we electrify 20,000km of highways that will definitely be be enough,” he added. “The distance between two highways is never more than 45km and electric cars can already travel that distance without needing to be recharged. Some believe it would be enough to electrify 5,000km.”

At a cost of €1m per kilometre, the cost of electrification is said to be 50 times lower than that required to construct an urban tram line.

Säll said: “There is no electricity on the surface. There are two tracks, just like an outlet in the wall. Five or six centimetres down is where the electricity is. But if you flood the road with salt water then we have found that the electricity level at the surface is just one volt. You could walk on it barefoot.”

National grids are increasingly moving away from coal and oil and battery storage is seen as crucial to a changing the source of the energy used in transportation.

Research: Wireless Energy Source that Generates Electricity from Simple Mechanical Motions Developed

This is cool research, but it’s difficult to determine how costly and efficient it would be at scale. Also, the W-TENG’s prototypical use of Teflon is definitely a concern, as Teflon’s C8 chemical is toxic to humans.

Researchers from Clemson’s Nanomaterials Institute (CNI) are one step closer to wirelessly powering the world using triboelectricity — a green energy source.

In March 2017, a group of physicists at CNI invented the ultra-simple triboelectric nanogenerator, or U-TENG — a small device made simply of plastic and tape that generates electricity from motion and vibrations. When the two materials are brought together — through clapping your hands or tapping your feet, for example — a voltage is generated that is detected by a wired, external circuit. Electrical energy, by way of the circuit, is then stored in a capacitor or a battery until it’s needed.

Nine months later, in a paper published in the journal Advanced Energy Materials, the researchers have uncovered a wireless version of TENG, called the W-TENG, which greatly expands the applications of the technology.

The W-TENG was engineered under the same premise as the U-TENG, using materials that are so opposite in affinity for electrons that they generate a voltage when brought in contact with each other.

In the W-TENG, plastic was swapped for a multipart fiber made of graphene — a single layer of graphite, or pencil lead — and a biodegradable polymer known as poly-lactic acid (PLA). PLA, on its own, is great for separating positive and negative charges, but not so great at conducting electricity — which is why the researchers paired it with graphene. Kapton tape, the electron-grabbing material of the U-TENG — was replaced with Teflon, a compound known for coating nonstick cooking pans.

“We use Teflon because it has a lot of fluorine groups that are highly electronegative, whereas the graphene-PLA is highly electropositive. That’s a good way to juxtapose and create high voltages,” said Ramakrishna Podila, corresponding author of the study and an assistant professor of physics at Clemson.

To obtain graphene, the researchers exposed its parent compound, graphite, to a high frequency sound wave. The sound wave then act as a sort of knife, slicing the “deck of cards” that is graphite into layer after layer of graphene. This process, called sonication, is how CNI is able to scale up production of graphene to meet the research and development demands of the W-TENG and other nanomaterial inventions in development.

After assembling the graphene-PLA fiber, the researchers exploited additive manufacturing — otherwise known as 3D printing — to pull the fiber into a 3D printer, and the W-TENG was born.

The end result is a device that generates a max voltage of 3000 volts — enough to power 25 standard electrical outlets, or on a grander scale, smart-tinted windows or a liquid crystal display (LCD) monitor. Because the voltage is so high, the W-TENG generates an electric field around itself that can be sensed wirelessly. Its electrical energy, too, can be stored wirelessly in capacitors and batteries.

“It cannot only give you energy, but you can use the electric field also as an actuated remote. For example, you can tap the W-TENG and use its electric field as a ‘button’ to open your garage door, or you could activate a security system — all without a battery, passively and wirelessly,” said Sai Sunil Mallineni, the first author of the study and a Ph.D. student in physics and astronomy.

[…]

As such, Podila says there is a definite philanthropic use for the team’s invention.

“Several developing countries require a lot of energy, though we may not have access to batteries or power outlets in such settings,” Podila said. “The W-TENG could be one of the cleaner ways of generating energy in these areas.”

The team of researchers, again led by Mallineni, is in the process of patenting the W-TENG through the Clemson University Research Foundation. Professor Apparao Rao, director of the Clemson Nanomaterials Institute, is also in talks with industrial partners to begin integrating the W-TENG into energy applications.

However, before industrial production, Podila says more research is being done to replace Teflon with a more environmentally friendly, electronegative material. A contender for the redesign is MXene, a two-dimensional inorganic compound that has the conductivity of a transition metal and the water-loving nature of alcohols like propanol. Yongchang Dong, another graduate student at CNI, led the work on demonstrating the MXene-TENG, which was published in a Nov. 2017 article in the journal Nano Energy. Herbert Behlow and Sriparna Bhattacharya from CNI also contributed to these studies.

Will the W-TENG make an impact in the realm of alternative, renewable energies? Rao says it will come down to economics.

“We can only take it so far as scientists; the economics need to work out in order for the W-TENG to be successful,” Rao said.

Germany Had Enough Energy to Essentially Pay People to Use It on Christmas

A clean energy surplus is a hopeful note for the future. Other countries besides should also make these big investments in renewable energy.

People in Germany essentially got paid to use electricity on Christmas.

Electricity prices in the country went negative for many customers – as in, below zero – on Sunday and Monday, because the country’s supply of clean, renewable power actually outstripped demand, according to The New York Times.

The phenomenon is less rare than you may think.

Germany has invested over US$200 billion in renewable power over the last few decades, primarily wind and solar.

During times when electricity demand is low – such as weekends when major factories are closed, or when the weather is unseasonably sunny – the country’s power plants pump more electricity into the grid than consumers actually need.

The disparity arises because wind and solar power are generally inconsistent. When the weather is windy or sunny, the plants generate a lot of electricity, but all that excess power is difficult to store. Battery technology is not quite advanced enough to fully moderate the supply to the grid.

So when the weather is hot, like it was in parts of Germany over the weekend, and most businesses are closed, plants generate an excess supply of power despite unusually low demand. Then it’s a matter of simple economics – prices, in effect, dip below zero.

It’s important to note that Germany’s utilities companies aren’t depositing money directly into consumer’s accounts when this happens. Rather, the periods of negative-pricing lead to lower electricity bills over the course of a year.

[…]

Traditional power grids – which mostly rely on fossil fuels to generate electricity – are designed so that output matches demand. But renewable energy technology hasn’t yet been developed to produce according to demand, since generation is a function of weather.

That’s “one of the key challenges in the whole transition of the energy market to renewable power,” Tobias Kurth, the managing director of Energy Brainpool, told the Times.

As storage technology lags behind the efficiency of renewable power sources, it’s likely that this negative-pricing situation will occur again. In that case, governments might need to provide incentives for people to increase their power usage when prices go negative.

These irregularities need to get figured out sooner rather than later, since renewable energy is growing rapidly, driven by the declining cost of technology and government subsidies. The International Energy Agency predicts that renewable energy will comprise 40 percent of global power generation by 2040.

In the next five years, the share of electricity generated by renewables worldwide is set to grow faster than any other source.

In Britain, renewable energy sources generated over triple the electricity as coal did in 2017, according to The Guardian. In June, during a particularly windy night, power prices actually went negative in Britain for a few hours as well – and it’s likely to happen again.