People Can Taste Flavor With Smell Receptors, Not Just Taste Ones

According to the latest research, the flavor of food is also a result of cell receptors associated with smelling things.

Scientists from the Monell Center report that functional olfactory receptors, the sensors that detect odors in the nose, are also present in human taste cells found on the tongue. The findings suggest that interactions between the senses of smell and taste, the primary components of food flavor, may begin on the tongue and not in the brain, as previously thought.

“Our research may help explain how odor molecules modulate taste perception,” said study senior author Mehmet Hakan Ozdener, MD, PhD, MPH, a cell biologist at Monell. “This may lead to the development of odor-based taste modifiers that can help combat the excess salt, sugar, and fat intake associated with diet-related diseases such as obesity and diabetes.”

While many people equate flavor with taste, the distinctive flavor of most foods and drinks comes more from smell than it does from taste. Taste, which detects sweet, salty, sour, bitter, and umami (savory) molecules on the tongue, evolved as a gatekeeper to evaluate the nutrient value and potential toxicity of what we put in our mouths. Smell provides detailed information about the quality of food flavor, for example, is that banana, licorice, or cherry? The brain combines input from taste, smell, and other senses to create the multi-modal sensation of flavor.

Until now, taste and smell were considered to be independent sensory systems that did not interact until their respective information reached the brain. Ozdener was prompted to challenge this belief when his 12-year-old son asked him if snakes extend their tongues so they can smell.

In the study, published online ahead of print in Chemical Senses, Ozdener and colleagues used methods developed at Monell to maintain living human taste cells in culture. Using genetic and biochemical methods to probe the taste cell cultures, the researchers found that the human taste cells contain many key molecules known to be present in olfactory receptors.

They next used a method known as calcium imaging to show that the cultured taste cells respond to odor molecules in a manner similar to olfactory receptor cells.

Together, the findings provide the first demonstration of functional olfactory receptors in human taste cells, suggesting that olfactory receptors may play a role in the taste system by interacting with taste receptor cells on the tongue. Supporting this possibility, other experiments by the Monell scientists demonstrated that a single taste cell can contain both taste and olfactory receptors.

“The presence of olfactory receptors and taste receptors in the same cell will provide us with exciting opportunities to study interactions between odor and taste stimuli on the tongue,” said Ozdener.

In addition to providing insight into the nature and mechanisms of smell and taste interactions, the findings also may provide a tool to increase understanding of how the olfactory system detects odors. Scientists still do not know what molecules activate the vast majority of the 400 different types of functional human olfactory receptors.

Advertisements

Using Chronoprinting to Cheaply Detect Food and Drug Impurities

The world has long needed this valuable sort of development to safeguard people’s health.

If we could tell authentic from counterfeit or adulterated drugs and foods just by looking at them, we could save money and lives every year, especially in the developing world, where the problem is worst. Unfortunately, the technologies that can detect what a sample is made of are expensive, energy-intensive, and largely unavailable in regions where they are needed most.

This may change with a simple new technique developed by engineers from the University of California, Riverside that can detect fake drugs from a video taken as the sample undergoes a disturbance.

If you’ve ever used online photo tools, you’ve probably seen how these tools use image analysis algorithms to categorize your photos. By distinguishing the different people in your photos, these algorithms make it easy to find all the photos of your daughter or your dad. Now, in the journal ACS Central Science, researchers report they have used these algorithms to solve a very different problem: identifying fake medicines and other potentially dangerous products.

Called “chronoprinting,” the technology requires only a few relatively inexpensive pieces of equipment and free software to accurately distinguish pure from inferior food and medicines.

The World Health Organization says that about 10 percent of all medicines in low- and middle-income countries are counterfeit, and food fraud is a global problem that costs consumers and industry billions of dollars per year. Fraudulent food and drugs waste money and jeopardize the health and lives of their consumers. But detecting fakes and frauds requires expensive equipment and highly trained experts.

William Grover, an assistant professor of bioengineering in UC Riverside’s Marlan and Rosemary Bourns College of Engineering, and Brittney McKenzie, a doctoral student in Grover’s lab, wondered if it would be possible to distinguish authentic from adulterated drugs and food by observing how they behave when disturbed by temperature changes or other causes. Two substances with identical compositions should respond the same way to a disturbance, and if two substances appear identical but respond differently, their composition must be different, they reasoned.

McKenzie designed a set of experiments to test this idea. She loaded samples of pure olive oil, one of the world’s most commonly adulterated foods, and cough syrup, which is often diluted or counterfeited in the developing world, into tiny channels on a microfluidic chip, and chilled it quickly in liquid nitrogen. A USB microscope camera filmed the samples reacting to the temperature change.

McKenzie and Grover wrote software that converts the video to a bitmap image. Because the image showed how the sample changed over time, the researchers called it a “chronoprint.”

The team then used image analysis algorithms to compare different chronoprints from the same substance. They found that each pure substance had a reliable chronoprint over multiple tests.

Next, they repeated the experiment with samples of olive oil that had been diluted with other oils and cough syrup diluted with water. The adulterated samples produced chronoprints that were different from the pure samples. The difference was so big, so obvious, and so consistent the researchers concluded that chronoprints and image analysis algorithms can reliably detect some types of food and drug fraud.

“The significant visual differences between the samples were both unexpected and exciting, and with them being consistent we knew this could be a useful way to identify a wide range of samples,” McKenzie said.

Grover said their technique creates a powerful new connection between chemistry and computer science.

“By basically converting a chemical sample to an image, we can take advantage of all the different image analysis algorithms that computer scientists have developed,” he said. “And as those algorithms get better, our ability to chemically identify a sample should get better, too.”

The researchers used liquids in their experiments but note the method could also be used on solid materials dissolved in water, and other types of disturbance, such as heat or a centrifuge, could be used for substances that don’t react well to freezing. The technique is easy to learn, making highly trained experts unnecessary. Chronoprinting requires hobbyist-grade equipment and software downloadable for free from Grover’s lab website, putting it well within reach of government agencies and labs with limited resources.

Video on how this chronoprinting works: https://youtu.be/qbyE68qD2Zo

Fracking Usage Linked to Increased Hospitalizations in Relevant Areas

There are numerous clean ways to generate electricity — continuing to rely on fossil fuels is again shown to have harmful effects.

New research has tied high rates of hospitalizations for genital, skin, and urinary conditions to fracking in Pennsylvania, underscoring mounting concerns about the public health implications of the controversial process of extracting natural gas.

Alina Denham, a Ph.D. candidate at the University of Rochester, led a research team that analyzed county-level hospital data for the state from 2003 to 2014. Their findings indicated that “long-term exposure to unconventional drilling may be harmful to population health.”

The conclusion bolstered previous findings about the dangers of fracking—a process also called hydraulic fracturing that involves injecting a mix of water and chemicals into the ground to access gas.

[…]

Although the team observed spikes in hospital stays for skin, genital, and urinary conditions as regional fracking rose, they did not examine what specifically led to those ailments. While calling for further research, they offered some potential explanations, which included documented dermatological effects of the chemicals used in fracking as well as studies that have linked drilling activity to risky sexual behaviors, which could help explain the genitourinary hospitalizations.

The research and subsequent warning from Denham’s team are especially alarming considering the Trump administration’s fossil fuel-friendly agenda.

However, even before President Donald Trump took office, Pennsylvania was a hotbed for fracking. In 2017, the state was  second only to Texas in terms of natural gas production, with much of the drilling focused on Marcellus Shale in Pennsylvania’s southwestern region.

And, as Denham emphasized, “it’s [an] important point to keep in mind that hospitalizations are for acute illness or serious exacerbations of chronic illness… So if we see strong associations with hospitalizations, it’s likely that additional cases of mild symptoms for the same illnesses have been addressed at home or in an outpatient setting, or not addressed at all.”

Two-Thirds of U.S. Bankruptcies Related to Medical Expenses

The dysfunctional U.S. healthcare system continues to impose serious costs on American families. One poll states that about half of U.S. doctors have considered quitting due to the ridiculous amount of paperwork that the profit-driven American healthcare system requires — they want to practice medicine, not paperwork. In the background, a strong majority of the U.S. public now supports Medicare for All.

For many Americans, putting one’s health first can mean putting one’s financial status at risk. A study of bankruptcy filings in the United States showed that 66.5% were due, at least in part, to medical expenses.

The study, led by Dr. David Himmelstein, Distinguished Professor at the City University of New York’s (CUNY) Hunter College and Lecturer at Harvard Medical School, indicates that about 530,000 families each year are financially ruined by medical bills and sicknesses. It’s the first research of its kind to link medical expenses and bankruptcy since the passage of the Affordable Care Act (ACA) in 2010.

“Unless you’re Bill Gates, you’re just one serious illness away from bankruptcy,” Himmelstein says in a release by the Physicians for a National Health Program. “For middle-class Americans, health insurance offers little protection. Most of us have policies with so many loopholes, copayments and deductibles that illness can put you in the poorhouse.”

Brain-Training App Has Research-Backed Claims to Improve User Concentration

The app could potentially be quite useful, but it should be noted that research has been finding what a good brain workout exercise is.

A new ‘brain training’ game designed by researchers at the University of Cambridge improves users’ concentration, according to new research published today. The scientists behind the venture say this could provide a welcome antidote to the daily distractions that we face in a busy world.

In their book, The Distracted Mind: Ancient Brains in a High-Tech World, Adam Gazzaley and Larry D. Rosen point out that with the emergence of new technologies requiring rapid responses to emails and texts and working on multiple projects simultaneously, young people, including students, are having more problems with sustaining attention and frequently become distracted. This difficulty in focussing attention and concentrating is made worse by stress from a global environment that never sleeps and also frequent travel leading to jetlag and poor quality sleep.

“We’ve all experienced coming home from work feeling that we’ve been busy all day, but unsure what we actually did,” says Professor Barbara Sahakian from the Department of Psychiatry. “Most of us spend our time answering emails, looking at text messages, searching social media, trying to multitask. But instead of getting a lot done, we sometimes struggle to complete even a single task and fail to achieve our goal for the day. Then we go home, and even there we find it difficult to ‘switch off’ and read a book or watch TV without picking up our smartphones. For complex tasks we need to get in the ‘flow’ and stay focused.”

In recent years, as smartphones have become ubiquitous, there has been a growth in the number of so-called ‘brain training’ apps that claim to improve cognitive skills such as memory, numerical skills and concentration.

Now, a team from the Behavioural and Clinical Neuroscience Institute at the University of Cambridge, has developed and tested ‘Decoder’, a new game that is aimed at helping users improve their attention and concentration. The game is based on the team’s own research and has been evaluated scientifically.

In a study published today in the journal Frontiers in Behavioural Neuroscience Professor Sahakian and colleague Dr George Savulich have demonstrated that playing Decoder on an iPad for eight hours over one month improves attention and concentration. This form of attention activates a frontal-parietal network in the brain.

In their study, the researchers divided 75 healthy young adults into three groups: one group received Decoder, one control group played Bingo for the same amount of time and a second control group received no game. Participants in the first two groups were invited to attend eight one-hour sessions over the course of a month during which they played either Decoder or Bingo under supervision.

All 75 participants were tested at the start of the trial and then after four weeks using the CANTAB Rapid Visual Information Processing test (RVP). CANTAB RVP has been demonstrated in previously published studies to be a highly sensitive test of attention/concentration.

During the test, participants are asked to detect sequences of digits (e.g. 2-4-6, 3-5-7, 4-6-8). A white box appears in the middle of screen, of which digits from 2 to 9 appear in a pseudo-random order, at a rate of 100 digits per minute. Participants are instructed to press a button every time they detect a sequence. The duration of the test is approximately five minutes.

Results from the study showed a significant difference in attention as measured by the RVP. Those who played Decoder were better than those who played Bingo and those who played no game. The difference in performance was significant and meaningful as it was comparable to those effects seen using stimulants, such as methylphenidate, or nicotine. The former, also known as Ritalin, is a common treatment for Attention Deficit Hyperactivity Disorder (ADHD).

To ensure that Decoder improved focussed attention and concentration without impairing the ability to shift attention, the researchers also tested participants’ ability on the Trail Making Test. Decoder performance also improved on this commonly used neuropsychological test of attentional shifting. During this test, participants have to first attend to numbers and then shift their attention to letters and then shift back to numbers. Additionally, participants enjoyed playing the game, and motivation remained high throughout the 8 hours of gameplay.

Professor Sahakian commented: “Many people tell me that they have trouble focussing their attention. Decoder should help them improve their ability to do this. In addition to healthy people, we hope that the game will be beneficial for patients who have impairments in attention, including those with ADHD or traumatic brain injury. We plan to start a study with traumatic brain injury patients this year.”

Dr Savulich added: “Many brain training apps on the market are not supported by rigorous scientific evidence. Our evidence-based game is developed interactively and the games developer, Tom Piercy, ensures that it is engaging and fun to play. The level of difficulty is matched to the individual player and participants enjoy the challenge of the cognitive training.”

The game has now been licensed through Cambridge Enterprise, the technology transfer arm of the University of Cambridge, to app developer Peak, who specialise in evidence-based ‘brain training’ apps. This will allow Decoder to become accessible to the public. Peak has developed a version for Apple devices and is releasing the game today as part of the Peak Brain Training app. Peak Brain Training is available from the App Store for free and Decoder will be available to both free and pro users as part of their daily workout. The company plans to make a version available for Android devices later this year.

“Peak’s version of Decoder is even more challenging than our original test game, so it will allow players to continue to gain even larger benefits in performance over time,” says Professor Sahakian. “By licensing our game, we hope it can reach a wide audience who are able to benefit by improving their attention.”

Fitness Misconceptions, According to Scientific Research

Suggestions for 2019 — exercise more and more is found to have major health benefits.

Whether you want to tone up, slim down, or boost your mood, you’ve likely taken a stab at tweaking your fitness routine. Unfortunately, there’s a lot of fitness advice out there that won’t help you meet your goals and could actually do more harm than good.

Here’s an overview of some of the most enduring workout myths and misconceptions, as well as the real science that can help you meet your fitness goals in a healthy way.

Myth #1: To stay in shape, you only need to work out once or twice a week.

Truth: Once or twice a week won’t cut it for sustained health benefits.

“A minimum of three days per week for a structured exercise program” is best, Shawn Arent, an exercise scientist at Rutgers University, recently told Business Insider.

“Technically, you should do something every day, and by something I mean physical activity – just move. Because we’re finding more and more that the act of sitting counteracts any of the activity you do.”

[…]

Myth #3: Weight lifting turns fat into muscle.

Truth: You can’t turn fat into muscle. Physiologically speaking, they’re two different tissues. Adipose (fatty) tissue is found under the skin, sandwiched between muscles, and around internal organs like the heart.

Muscle tissue – which can be further broken down into three main types – is found throughout the body.

What weight training really does is help build up the muscle tissue in and around any fat tissue. The best way to reduce fat tissue is to eat a healthy diet that incorporates vegetables, whole grains, lean proteins and – somewhat paradoxically – healthy fats like olive oil and fish.

Myth #4: Puzzles and games are the best ‘brain workout’ around.

Truth: Plain old physical exercise seems to beat out any type of mental puzzle available, according to a wealth of recent research.

Two new studies published this spring suggest that aerobic exercise – any activity that raises your heart rate and gets you moving and sweating for a sustained period of time – has a significant, overwhelmingly beneficial impact on the brain.

“Aerobic exercise is the key for your head, just as it is for your heart,” wrote the authors of a recent Harvard Medical School blog post.

Myth #5: Exercise is the best way to lose weight.

Truth: If you’re looking to lose weight, you shouldn’t assume that you can simply ‘work off’ whatever you eat. Experts say slimming down almost always starts with significant changes to your eating habits.

“In terms of weight loss, diet plays a much bigger role than exercise,” University of Texas exercise scientist Philip Stanforth tells Business Insider.

That said, being active regularly is an important part of any healthy lifestyle.

And when it comes to boosting your mood, improving your memory, and protecting your brain against age-related cognitive decline, research suggests exercise may be as close to a wonder drug as we’ll get.

Myth #6: Sit-ups are the best way to get six-pack abs.

Truth: As opposed to sit-ups, which target only your abdominal muscles, planks recruit several groups of muscles along your sides, front, and back. If you want a strong core – especially the kind that would give you six-pack-like definition – you need to challenge all of these muscles.

“Sit-ups or crunches strengthen just a few muscle groups,” write the authors of the Harvard Healthbeat newsletter.

“Through dynamic patterns of movement, a good core workout helps strengthen the entire set of core muscles you use every day.”

Myth #7: Weight training is for men.

Truth: Weight training is a great way to strengthen muscles, and has nothing to do with gender. That said, women produce less testosterone on average than men do, and studies suggest that hormone plays a role in determining how we build muscle.

Myth #8: It takes at least two weeks to get ‘out of shape’.

Truth: In most people, muscle tissue can start to break down within a week without regular exercise.

“If you stop training, you actually do get noticeable de-conditioning, or the beginnings of de-conditioning, with as little as seven days of complete rest,” Arent said. “It very much is an issue of use it or lose it.”

Myth #9: Running a marathon is the ideal way to get fit.

Truth: Not ready to conquer a marathon? No problem. You can get many of the benefits of long-distance running without ever passing the five-mile mark.

Running fast and hard for just 5 to 10 minutes a day can provide some of the same health outcomes as running for hours can.

In fact, people who run for less than an hour a week – as long as they get in those few minutes each day – see similar benefits in terms of heart health compared to those who run more than three hours per week.

Plus, years of recent research suggest that short bursts of intense exercise can provide some of the same health benefits as long, endurance-style workouts – and they also tend to be more fun.

New Materials for Wound and Skin Healing

Good research into healing — it leverages the body’s own natural resources.

Materials are widely used to help heal wounds: Collagen sponges help treat burns and pressure sores, and scaffold-like implants are used to repair bones. However, the process of tissue repair changes over time, so scientists are developing biomaterials that interact with tissues as healing takes place.

Now, Dr Ben Almquist and his team at Imperial College London have created a new molecule that could change the way traditional materials work with the body. Known as traction force-activated payloads (TrAPs), their method lets materials talk to the body’s natural repair systems to drive healing.

The researchers say incorporating TrAPs into existing medical materials could revolutionise the way injuries are treated. Dr Almquist, from Imperial’s Department of Bioengineering, said: “Our technology could help launch a new generation of materials that actively work with tissues to drive healing.”

The findings are published today in Advanced Materials.

Cellular call to action

After an injury, cells ‘crawl’ through the collagen ‘scaffolds’ found in wounds, like spiders navigating webs. As they move, they pull on the scaffold, which activates hidden healing proteins that begin to repair injured tissue.

The researchers designed TrAPs as a way to recreate this natural healing method. They folded the DNA segments into three-dimensional shapes known as aptamers that cling tightly to proteins. Then, they attached a customisable ‘handle’ that cells can grab onto on one end, before attaching the opposite end to a scaffold such as collagen.

During laboratory testing of their technique, they found that cells pulled on the TrAPs as they crawled through the collagen scaffolds. The pulling made the TrAPs unravel like shoelaces to reveal and activate the healing proteins. These proteins instruct the healing cells to grow and multiply.

The researchers also found that by changing the cellular ‘handle’, they can change which type of cell can grab hold and pull, letting them tailor TrAPs to release specific therapeutic proteins based on which cells are present at a given point in time. In doing so, the TrAPs produce materials that can smartly interact with the correct type of cell at the correct time during wound repair.

This is the first time scientists have activated healing proteins using different types of cells in human-made materials. The technique mimics healing methods found in nature. Dr Almquist said: “Using cell movement to activate healing is found in creatures ranging from sea sponges to humans. Our approach mimics them and actively works with the different varieties of cells that arrive in our damaged tissue over time to promote healing.”

From lab to humans

This approach is adaptable to different cell types, so could be used in a variety of injuries such as fractured bones, scar tissue after heart attacks, and damaged nerves. New techniques are also desperately needed for patients whose wounds won’t heal despite current interventions, like diabetic foot ulcers, which are the leading cause of non-traumatic lower leg amputations.

TrAPs are relatively straightforward to create and are fully human-made, meaning they are easily recreated in different labs and can be scaled up to industrial quantities. Their adaptability also means they could help scientists create new methods for laboratory studies of diseases, stem cells, and tissue development.

Aptamers are currently used as drugs, meaning they are already proven safe and optimised for clinical use. Because TrAPs take advantage of aptamers that are currently optimised for use in humans, they may be able to take a shorter path to the clinic than methods that start from ground zero.

Dr Almquist said: “The TrAP technology provides a flexible method to create materials that actively communicate with the wound and provide key instructions when and where they are needed. This sort of intelligent, dynamic healing is useful during every phase of the healing process, has the potential to increase the body’s chance to recover, and has far-reaching uses on many different types of wounds. This technology has the potential to serve as a conductor of wound repair, orchestrating different cells over time to work together to heal damaged tissues.”