Peptide-Based Dental Product May Rebuild Cavities

It’s amazing that the drill method is still prevalent in 2018. New approaches that use substances such as peptides and lasers are the innovations of the future.

Researchers at the University of Washington have designed a convenient and natural product that uses proteins to rebuild tooth enamel and treat dental cavities.

The research finding was first published in ACS Biomaterials Science and Engineering.

“Remineralization guided by peptides is a healthy alternative to current dental health care,” said lead author Mehmet Sarikaya, professor of materials science and engineering and adjunct professor in the Department of Chemical Engineering and Department of Oral Health Sciences.

The new biogenic dental products can — in theory — rebuild teeth and cure cavities without today’s costly and uncomfortable treatments.

“Peptide-enabled formulations will be simple and would be implemented in over-the-counter or clinical products,” Sarikaya said.

Cavities are more than just a nuisance. According to the World Health Organization, dental cavities affect nearly every age group and they are accompanied by serious health concerns. Additionally, direct and indirect costs of treating dental cavities and related diseases have been a huge economic burden for individuals and health care systems.

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Taking inspiration from the body’s own natural tooth-forming proteins, the UW team has come up with a way to repair the tooth enamel. The researchers accomplished this by capturing the essence of amelogenin — a protein crucial to forming the hard crown enamel — to design amelogenin-derived peptides that biomineralize and are the key active ingredient in the new technology. The bioinspired repair process restores the mineral structure found in native tooth enamel.

“These peptides are proven to bind onto tooth surfaces and recruit calcium and phosphate ions,” said Deniz Yucesoy, a co-author and a doctoral student at the UW.

The peptide-enabled technology allows the deposition of 10 to 50 micrometers of new enamel on the teeth after each use. Once fully developed, the technology can be used in both private and public health settings, in biomimetic toothpaste, gels, solutions and composites as a safe alternative to existing dental procedures and treatments. The technology enables people to rebuild and strengthen tooth enamel on a daily basis as part of a preventive dental care routine. It is expected to be safe for use by adults and children.

Creator of Signal to Potentially Transform the Usage of Cryptocurrency

Signal by Open Whisper Systems transformed the world of encrypted messaging and encrypted calling. Beyond that, the Signal Protocol (formerly called the Axolotl ratchet) that the brilliant cryptographic engineer Moxie Marlinspike helped design has vastly improved the usage of end-to-end encryption for hundreds of millions of people. Apparently Marlinspike has been working on improving the functionality of cryptocurrency for the masses lately, and based on his past work, he will probably have a significant impact on that area too.

Cryptocurrency remains confusing and challenging for the average person to acquire and manage, much less sell. And the protocols that underlie bitcoin and other mainstream cryptocurrencies like ethereum suffer significant scalability and transaction bottleneck issues. Visa currently processes about 3,674 transactions per second; the best bitcoin network might be able to process seven per second.

But now the creator of the dead simple end-to-end encrypted messaging app SignalMoxie Marlinspike, is on a mission to overcome those limitations, and to create a streamlined digital currency that’s private, easy-to-use, and allows for quick transactions from any device. And while it may feel like the last thing the world needs is yet another cryptocurrency, Marlinspike’s track record with Signal—and the organization behind it, Open Whisper Systems—makes this a project worth watching.

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MobileCoin wants to leverage an extensive architecture to add simplicity to real privacy protections and resilience against attacks. The ultimate goal: To make MobileCoin as intuitive as any other payment system.

That vision mirrors the animating purpose of Signal, which was developed to make robust end-to-end encrypted communication as easy and straightforward as less secure options, a simple experience that belies the complex cryptographic communication protocols that enable it.

“I think usability is the biggest challenge with cryptocurrency today,” says Marlinspike. “The innovations I want to see are ones that make cryptocurrency deployable in normal environments, without sacrificing the properties that distinguish cryptocurrency from existing payment mechanisms.”

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There are lots of potential applications for MobileCoin, but Goldbard and Marlinspike envision it first as an integration in chat apps like Signal or WhatsApp. Here’s how it would work in practice: To start using MobileCoin, you would generate a public and private key, and a recovery PIN. Then you would set up your account with an app that incorporates MobileCoin. The app would validate the software running in its service’s node, establish an encrypted communication channel to the enclave, and then send your keys and the short, easy-to-remember recovery PIN that you’ll use to access your MobileCoin—like a smartphone lock passcode.

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And though speculation has driven bitcoin to all-time-high valuations, most cryptocurrencies don’t end up capturing much value, languishing instead in far-flung corners of the internet. Here again, though, MobileCoin’s creators hope to emulate Signal. End-to-end encryption was once a fringe feature; then WhatsApp gave it to a billion people at once using the Signal Protocol.